FGF-23 Is Elevated by Chronic Hyperphosphatemia
نویسندگان
چکیده
منابع مشابه
FGF-23 and Hyperphosphatemia in Dialysis Dependent Chronic Kidney Disease Patients
Dialysis dependent chronic kidney disease (CKD) has become a worldwide public health problem. It is known to increase patient morbidity and mortality risks which can cause major economic strain on the health-care systems. A population based study has shown that the incidence of this end stage renal disease (ESRD) in India was 160 per million population (p.m.p.) in the year 2008 [1]. One of the ...
متن کاملEarly post-transplantation hypophosphatemia is associated with elevated FGF-23 levels.
BACKGROUND We examined the hypothesis that high FGF-23 levels early after transplantation contribute to the onset of hypophosphatemia, independently of parathyroid hormone (PTH) and other factors regulating phosphate metabolism. METHODS We measured serum phosphate levels (sPi), renal tubular reabsorption of Pi (TmPi/GFR), estimated GFR (eGFR), intact PTH (iPTH), calcitriol, intact (int) and C...
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Joseph Wang, Beth Vogt, Sidharth Kumar Sethi, Matthew G. Sampson, Virginia Vega-Warner, Edgar A. Otto and Rupesh Raina Lake Erie College of Osteopathic Medicine, Erie, Pennsylvania, USA; Pediatric Nephrology, Rainbow Babies and Children’s Hospital at Case Western Reserve University, Cleveland, Ohio, USA; Pediatric Nephrology, Kidney Institute, Medanta, The Medicity, Gurgaon, Haryana, India, 122...
متن کاملClinical significance of FGF-23 in Chronic Kidney Disease Patients
Fibroblast growth factor 23 (FGF-23) is a potent regulator of serum phosphate level. In CKD, circulating FGF-23 levels gradually increase with declining renal function. Higher FGF-23 level was associated with higher atherosclerosis score. We aimed to study the correlation between FGF-23 and the parameters that have effects on morbidity and mortality in CKD patients and to establish its role as ...
متن کاملPhosphate and FGF-23
Fibroblast growth factor (FGF)-23 is probably the most important regulator of serum phosphate and calcitriol (1,25(OH)₂D₃) levels. It is secreted by osteocytes and osteoblasts in response to oral phosphate loading or increased serum 1,25(OH)₂D₃ levels. In human chronic kidney disease (CKD), plasma FGF-23 appears to be a sensitive biomarker of abnormal renal phosphate handling, as FGF-23 levels ...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2004
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2004-0724